Sepheo sa rona sa mantlha e tla ba ho u fa bareki ba rona likamano tse tebileng le tse nang le boikarabello ba khoebo, ho fana ka tlhokomelo ea motho ka mong bakeng sa Khetho e kholo ea Pepsin NF, Rea u amohela hore u hlahlobe lefapha la rona la tlhahiso le ho lebella ho theha likamano tse amohelehang tsa khoebo le bareki lapeng la hau le kantle ho naha ka har'a tikoloho ea nako e telele.
Sepheo sa rona sa mantlha e tla ba ho u fa bareki ba rona kamano e tebileng le e nang le boikarabelo ba khoebo, ho fana ka tlhokomelo ea botho ho bona kaofela bakeng saChina Active Pharmaceutical motsoako le Monko oa Lik'hemik'hale, Ho finyella melemo e phelisanang, k'hamphani ea rona e matlafatsa ka ho pharaletseng maqheka a rona a ho ikopanya ha lichaba tsa lefatše mabapi le puisano le bareki ba mose ho maoatle, ho fana ka potlako, boleng bo botle ka ho fetisisa le tšebelisano ea nako e telele.Khamphani ea rona e ts'ehetsa moea oa "boqapi, kutloano, mosebetsi oa sehlopha le ho arolelana, litsela, tsoelo-pele ea pragmatic".Re fe monyetla mme re tla paka bokhoni ba rona.Ka thuso ea hau e mosa, re lumela hore re ka theha bokamoso bo khanyang le uena hammoho.
1. Litlhaku: E tšoeu kapa e mosehla hanyenyane, crystalline kapa phofo ea amorphous.
2. Mohloli oa Mohloli: Porcine gastric mucosa.
3. Ts'ebetso: Pepsin e arohane le mucosa ea ka mpeng ea kolobe e sebelisa mokhoa o ikhethang oa ho ntša.
4. Lipontšo le tšebeliso: E sebelisoa haholo bakeng sa dyspepsia e bakoang ke ho feta ho ja lijo tse nang le protheine, hypofunction ea tšilo ea lijo nakong ea ho hlaphoheloa le khaello ea protheine ea mala e bakoang ke atrophic gastritis e sa foleng, kankere ea mala le malignant anemia.Pepsin ke enzyme e hlahisoang tseleng ea tšilo ea lijo ea liphoofolo tse anyesang.E sebetsa ho pshatla liprotheine hore e be li-peptide tse nyane tse ka monngoang habonolo ke mala a manyane.
5. Liketso tsa Biochem / physiol: Ho fapana le li-peptidase tse ling tse ngata, pepsin hydrolyzes feela li-bond tsa peptide, eseng li-amide kapa ester linkages.Sebopeho sa cleavage se kenyelletsa li-peptide tse nang le asiti e nkhang hamonate ka mahlakoreng ka bobeli a bond ea peptide, haholo haeba masala a mang le ona e le amino acid e nkhang hamonate kapa ea dicarboxylic.Keketseho ea ts'oaetso ea hydrolysis e etsahala haeba ho na le amino acid e nang le sebabole haufi le bond ea peptide, e nang le amino acid e nkhang hamonate.Pepsin e tla boela e khephohe ka lehlakoreng la carboxyl la phenylalanine le leucine, le ho isa tekanyong e nyane lehlakoreng la carboxyl la masala a glutamic acid.Ha e kopane le li-link tsa valine, alanine, kapa glycine.ZL-tyrosyl-L-phenylalanine, ZL-glutamyl-L-tyrosine, kapa ZL-methionyl-L-tyrosine e ka sebelisoa e le li-substrates bakeng sa tšilo ea pepsin.Pepsin e thibetsoe ke li-peptide tse 'maloa tse nang le phenylalanine.
· E fetisitse Chinese GMP le EU GMP
· Lilemo tse 27 tsa nalane ea enzyme ea bioloji ea R&D
· Lisebelisuoa tse tala lia lateloa
·Lumellana le CP,EP,USP le maemo a bareki
·Mosebetsi o phahameng, bohloeki bo phahameng, botsitso bo phahameng
· Romella kantle ho naha le libakeng tse fetang 30
·E na le bokhoni ba tsamaiso ea boleng bo kang US FDA, Japan PMDA, South Korea MFDS, joalo-joalo.
Lintho tsa Tlhahlobo | Tlhaloso ea Khampani | |||
CP | EP | USP | ||
Litlhaku | phofo e tšoeu ho isa ho mosehla o khanyang; | E tšoeu kapa e mosehla hanyane, | E tšoeu kapa e mosehla hanyane, | |
ha ho na hlobo le deodorant;hygroscopic, | phofo ea crystalline kapa amorphous | phofo ea crystalline kapa amorphous | ||
tharollo ea metsi e bontša karabelo ea asiti | ||||
Boitsebiso | E lumellana | E lumellana | E lumellana | |
Liteko | Tahlehelo ka ho omisa | ≤ 5.0% (Tikoloho e omileng100℃, 4h) | ≤ 5.0% (670Pa 60℃, 4h) | ≤ 5.0% (Vacuum decompression 60℃, 4h) |
Mokelikeli o setseng | ———— | ≤ 5.0% Ho latela EP(5.4) | ≤ 5.0% Ho latela USP(467) | |
Tlhahlobo | 3800~12000U/g | 0.5–4.5Ph.Eur.U./mg | 3000~20000NF.U/mg | |
Kokoana | TAMC | ≤5X103cfu/g | ≤ 10000cfu/g | ≤ 10000cfu/g |
Litšila | TYMC | ≤ 100cfu/g | ≤ 100cfu/g | ≤ 100cfu/g |
E.coli | E lumellana | E lumellana | E lumellana | |
Salmonella | E lumellana | E lumellana | E lumellana |
Sepheo sa rona sa mantlha e tla ba ho u fa bareki ba rona likamano tse tebileng le tse nang le boikarabello ba khoebo, ho fana ka tlhokomelo ea motho ka mong bakeng sa Khetho e kholo ea Pepsin NF, Rea u amohela hore u hlahlobe lefapha la rona la tlhahiso le ho lebella ho theha likamano tse amohelehang tsa khoebo le bareki lapeng la hau le kantle ho naha ka har'a tikoloho ea nako e telele.
Khetho e kholo bakeng saChina Active Pharmaceutical motsoako le Monko oa Lik'hemik'hale, Ho finyella melemo e phelisanang, k'hamphani ea rona e matlafatsa ka ho pharaletseng maqheka a rona a ho ikopanya ha lichaba tsa lefatše mabapi le puisano le bareki ba mose ho maoatle, ho fana ka potlako, boleng bo botle ka ho fetisisa le tšebelisano ea nako e telele.Khamphani ea rona e ts'ehetsa moea oa "boqapi, kutloano, mosebetsi oa sehlopha le ho arolelana, litsela, tsoelo-pele ea pragmatic".Re fe monyetla mme re tla paka bokhoni ba rona.Ka thuso ea hau e mosa, re lumela hore re ka theha bokamoso bo khanyang le uena hammoho.